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擅長(zhǎng)領(lǐng)域：病理研究。?

執(zhí)業(yè)經(jīng)歷： 【學(xué)歷及工作背景】 1999.9-2004.7 山東大學(xué)醫(yī)學(xué)院(原山東醫(yī)科大學(xué))本科/學(xué)士 2004.9-2007.7 中山大學(xué)醫(yī)學(xué)院(原中山醫(yī)科大學(xué))碩士 【臨床工作及科研工作】 2009.12-至今 助理研究員 中山大學(xué)附屬第六醫(yī)院 2007.7-2009.12 實(shí)習(xí)研究員 中山大學(xué)附屬第六醫(yī)院 【主持及參加科研項(xiàng)目】 1. 在三維細(xì)胞培養(yǎng)模型中Aurora-A激酶磷酸化調(diào)控AKT2促進(jìn)結(jié)直腸癌遷徙轉(zhuǎn)移機(jī)制的研究。國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目(2010年，項(xiàng)目編號(hào)：81001086)：第一負(fù)責(zé)人，在研 2. Aurora-A激酶在三維培養(yǎng)模型中對(duì)結(jié)直腸癌浸潤(rùn)轉(zhuǎn)移的致癌特性研究。廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金(2010年，項(xiàng)目編號(hào)：WSTJJ20091225142431198101210628);第一負(fù)責(zé)人，在研 3. Aurora-A激酶磷酸化調(diào)控AKT2促進(jìn)結(jié)直腸癌遷徙轉(zhuǎn)移機(jī)制的研究。廣東高校優(yōu)秀青年創(chuàng)新人才培育項(xiàng)目(2010，項(xiàng)目編號(hào)：LYM10010)：第一負(fù)責(zé)人，在研 4. 結(jié)直腸癌三維培養(yǎng)模型中p75NGFR高甲基化活化MKK4促進(jìn)細(xì)胞侵襲轉(zhuǎn)移的機(jī)制研究。國(guó)家自然科學(xué)基金(2011年，項(xiàng)目編號(hào)：81172040)：第二負(fù)責(zé)人，在研 5. miR-21下調(diào)PTEN促進(jìn)結(jié)直腸癌上皮間質(zhì)轉(zhuǎn)化的機(jī)制研究。教育部新教師基金(2010年，項(xiàng)目編號(hào)：20100171120095)：第二負(fù)責(zé)人，在研 6. miR-21參與結(jié)直腸癌中EMT轉(zhuǎn)化的機(jī)制研究。廣東省醫(yī)學(xué)科研基金(2010年，項(xiàng)目編號(hào)：B2010124)：第二負(fù)責(zé)人，在研 7. 利用HRM技術(shù)進(jìn)行腸癌患者外周血和癌組織中DPYD基因的突變分析。中山大學(xué)附屬第六醫(yī)院青年創(chuàng)新人才培育項(xiàng)目(2010年，項(xiàng)目編號(hào)：303050795)：第二負(fù)責(zé)人，在研 8. 三維細(xì)胞培養(yǎng)模擬臨床缺氧狀態(tài)下HIF-1a轉(zhuǎn)錄調(diào)節(jié)Aurora激酶誘發(fā)鼻咽癌放療抵抗的分子機(jī)制。國(guó)家自然科學(xué)基金(2010年，項(xiàng)目編號(hào)：81071890)，第三負(fù)責(zé)人，在研 9. 鼻咽癌三維培養(yǎng)模型中HIF-1a轉(zhuǎn)錄調(diào)控Aurora激酶促進(jìn)細(xì)胞遷徙轉(zhuǎn)移機(jī)制的研究。國(guó)家自然科學(xué)基金(2010年，項(xiàng)目編號(hào)：81000934)，第四負(fù)責(zé)人，在研 【發(fā)表文章】 1. Xin-Juan Fan, Xiang-Bo Wan, Yan Huang, Hong-Min Cai, Xin-Hui Fu, Zu-Li Yang, Dian-Ke Chen, Shun-Xin Song, Pei-Huang Wu, Quentin Liu, Lei Wang, and Jian-Ping Wang. Epithelial-mesenchymal transition biomarkers and support vector machine guided model in preoperatively predicting regional lymph node metastasis for rectal cancer. British Journal of Cancer. (2012, in press, 2010 IF: 4.831) 2. Xin-Juan Fan, Xiang-Bo Wan, Zu-Li Yang, Xin-Hui Fu, Yan Huang, Dian-Ke Chen, Shun-Xin Song, Quentin Liu, Huan-Yu Xiao, Lei Wang, Jian-Ping Wang. Snail promotes lymph node metastasis, and Twist enhances tumor deposit formation through EMT in colorectal cancer. Human Pathology.(2012, in press, 2010 IF:2.998) 3. Xiang-Bo Wan, Yan Zhao, Xin-Juan Fan, Hong-Min Cai, Yan Zhang, Ming-Yuan Chen, Jie Xu, Xiang-Yuan Wu, Hong-Bo Li, Yi-Xin Zeng, Ming-Huang Hong, Quentin Liu.Molecular Prognostic Prediction for Locally Advanced Nasopharyngeal Carcinoma by Support Vector Machine Integrated Approach. Plos One.(共同第一作者，2012, in press, doi: 10.1371/journal.pone.0031989, 2010 IF: 4.411) 4. Wan XB, Fan XJ, Chen MY, Xiang J, Huang PY, Guo L, Wu XY, Xu J, Long ZJ, Zhao Y, Zhou WH, Mai HQ, Liu Q, Hong MH. Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy. 2010 Apr 26;6(3):395-404.(共同第一作者，2010 IF：6.829) 5. Wan XB, Fan XJ, Chen MY, Xu J, Long ZJ, Hua YJ, Ji H, Liu L, Hong MH, Zeng YX, Liu Q. Inhibition of Aurora-A results in increased cell death in 3-dimensional culture microenvironment, reduced migration and is associated with enhanced radiosensitivity in human nasopharyngeal carcinoma. Cancer Biol Ther. 2009 Aug;8(15):1500-6.(共同第一作者, 2010 IF：2.711) 6. Chen JN, Jiang Y, Li HG, Ding YG, Fan XJ, Xiao L, Han J, Du H, Shao CK. Epstein-Barr virus genome polymorphisms of Epstein-Barr virus-associated gastric carcinoma in gastric remnant carcinoma in Guangzhou, southern China, an endemic area of nasopharyngeal carcinoma. Virus Res. 2011 Sep;160(1-2):191-9. 7. Shunxin Song, Dianke Chen, Jiachun Lu, Jiawei Liao, Yanxin Luo, Zuli Yang, Xinhui Fu, Xinjuan Fan, Yisheng Wei, Lei Yang, Lei Wang, Jianping Wang.NFkB1 and NFkBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population. Plos One, 2011, 6(6):e21726. 8. Dianke Chen, Shunxin Song, Jiachun Lu,Yanxin Luo, Zuli Yang, Qinghua Huang, XinhuiFu, Xinjuan Fan,Yisheng Wei, JianpingWang, LeiWang.Functional variants of -1318T > G and -673C > T in c-Jun promoter region associated with increased colorectal cancer risk by elevating promoter activity. Carcinogenesis. 2011, 32(7): 1043-1049. 9. Zun-Fu Ke, Feng Zhou, Lian-Tang Wang, Shao-Hong Chen, Fang Liu, Xin-Juan Fan, Fang Tang, Da-Wei Liu, Guo-Qiang Zhao.Down-regulation of Wnt signaling could promote bone marrow-derived mesenchymal stem cells to differentiate into hepatocytes. Biochem Biophys Res Commun. 2008，367(2):342-348. 詳細(xì)介紹